Polarized proliferation is a critical determinant of correct stem cell differentiation, 48 — 52 and this might explain why disruption in the polarity of glomerular epithelial stem cells initiates abnormal proliferation and the development of hyperplastic glomerular lesions impairing recovery Figure 3 A.
However, numerous areas of podocyte injury distort glomerular structural integrity, thus altering the polarity of glomerular epithelial stem cell division and initiating their abnormal proliferation and the development of extracapillary hyperplastic lesions as well as crescents.
While it could be very difficult to use iPS cells for heart attacks given the lag time needed to produce and validate them from every new patient, for heart failure iPS cells seem like a great tool.
Conclusions Podocyte loss is a central determinant of progression to glomerulosclerosis. B Replacement of podocytes under physiologic conditions follows a gradient, with neo-podocytes progressively added at the vascular stalk.
I do wish the article had been more incisive about the challenges. What about stem cell headlines of the week? In a new study, Eppert and colleagues use gene expression signatures to analyze leukemia stem cells LSCs and hematopoietic stem cells HSCs in primary samples from patients with acute myelogenous leukemia AML.
Cancer stem cells are controlled by developmental networks that are often topologically indistinguishable from normal, healthy stem cells. Dysregulated glomerular epithelial stem cells create their own lesions. Macrophages green can also be included within the lesions.
Good Making iPS cells from heart failure patients has a lot of potential. Dysfunctional nerves seem to be at the root of a lot of pain and maybe stem cells can be used to make a therapy to fix that.
Footnotes Published online ahead of print. These intriguing results need to be validated in a randomized clinical trial of a large cohort of AML patients. Good The promise of stem cells for drug development is discussed at Nature. It indicates that the best therapeutic approach is to tackle the highest order stem cells first, otherwise spontaneous remission of so called cured cancers will always be a danger.
Accordingly, a recent study demonstrates that podocyte damage leads to glomerular injury with a complete histologic pattern of collapsing glomerulopathy related to high parietal epithelial cell proliferation in mice with null alleles for the cell cycle inhibitor, p21, compared with segmental lesions and mild intraglomerular proliferation in wild-type mice.
Eric Werner Submitted on 1 Aug Abstract: In addition to this list, there is evidence that some cancers may originate from a small pool of so-called cancer stem cells CSCs. More importantly, when LSC- and HSC-related gene signatures were examined in a cohort of cytogenetically normal AML patients, both signatures correlated negatively with overall survival.
The difference between cancer stem cells and normal stem cells lies not in differences their network architecture, but rather in the spatial-temporal locality of their activation in the genome and the resulting expression in the body.
Understanding of how self-renewal and fate decisions of glomerular epithelial stem cells are perturbed or modulated will be of crucial importance in obtaining novel tools for the prevention and treatment of glomerulosclerosis.
Additional confirmation of this hypothesis comes from lineage-tracing experiments performed in transgenic mice with genetically labeled parietal epithelial cells in the nephrotoxic nephritis model of crescentic glomerulonephritis and also the Thy Publication date available at www.
Sir Richard Roberts said: Numerous areas of podocyte injury along with glomerular epithelial stem cells proliferation heavily distort glomerular architecture, thus altering the polarity of stem cells division.
Taken together, the results of these recent studies suggest the clinicopathologic features of different glomerular disorders more likely represent distinct patterns of injury or repair rather than diseases.
Not surprisingly this week the anti-stem cell forces have used this as a weapon to bomb stem cell research and Rush has picked up on that stink bomb only making it stinkier.
A After massive podocyte injury, glomerular epithelial stem cells red generate cell bridges with the glomerular tuft in several areas of the glomerulus to quickly replace lost podocytes light blue.
Download powerpoint Figure 3. However, this regenerative process is sometimes inadequate because of an inefficient proliferative response by glomerular epithelial stem cells, as it may occur in aging patients or after FSGS Figure 2.
Similar processes might occur in crescentic glomerulonephritis and collapsing glomerulopathy. This idea is discussed based on some new research. The question is why cancer stem cells can be both phenotypically distinct and have morphological effects so different from normal stem cells.
Stem cell networks point to a pathway to new methods to diagnose and cure not only stem cell cancers but cancers generally. Bad An article from the financial sector cluster bombs stem cell-related biotechs from both financial and other angles.
On this basis, Haas and Yousefzadeh 79 argue that the tip lesion is a response to prolonged heavy proteinuria. Using a mouse xenograft assay, they tested each fraction to see whether they contained LSCs.Glomerular Epithelial Stem Cells: The Good, The Bad, and The Ugly Laura Lasagni* and Paola Romagnani*† *Excellence Centre for Research, Transfer and High Education for the development of De Novo Therapies (DENOTHE).
There is still confusion about stem cells and recently there has been some good, bad, and downright ugly information coming to light. The Good. One of the good things about stem cells is that they are not all the same.
The Miami Project has written several articles in the past about stem cells and their potential as therapeutics for spinal cord injury (SCI).
It’s been a wild week on this blog with many thoughts going out to the future of stem cells in Texas. Some wildness there too and lots of discussion of translational applications, which is exciting.
This week let’s start in reverse order with the ugly and what better way to begin than with Rush. STEM CELLS: THE BAD VS. THE GOOD THE BACKGROUND The use of embryonic stem cells to treat human diseases; is it unethical, questionable, helpful, in violation of law and policy or just the right answer for many, many diseases?
Glomerular Epithelial Stem Cells: The Good, The Bad, and The Ugly. The Good: Glomerular Epithelial Stem Cells Regenerate Podocytes. Limits and Defaults in the Regenerative Potential of Glomerular Epithelial Stem Cells; The Ugly: Dysregulated Glomerular Epithelial Stem Cells Create Their Own Lesions.Download